In the United States, about one in every babies is born with cleft lip and/or palate. “Folic acid deficiency causes facial clefts in laboratory animals, so we had a good reason to focus on folic acid in our clefts study,” said Wilcox. “It was one of our main hypotheses.”. Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft lip, cleft palate, and both together. A cleft lip contains an opening in the upper lip that may extend into the nose. The opening may be on one side, both sides, or in the middle.
Rare craniofacial clefts are severe deformities of the face and head that affect both bones and soft tissues. Clefts are formed in utero when normal development of a baby’s head and neck are disrupted and parts of the face fail to fuse together, creating facial and/or cranial differences. May 16, · Facial defects and neural tube defects are the most common forms of birth defects found in newborns. The most prevalent form of birth defect is orofacial cleft. The incidence rate is twice as common in Asians than the Caucasians.
Cleft lip and palate are birth defects of the mouth and lip, also known as oral-facial clefts. A normal fetus has a split lip and palate, but early in pregnancy, the sides of the lip and the roof of the mouth should fuse. Failure of fusion results in cleft lip and/or cleft palate.